LABORATORY OF IMMUNOLOGY AND BIOLOGY OF METASTASIS

RESEARCH


Immunological prevention of cancer

The aim of this project is to inhibit carcinogenesis using vaccines and other immunological approaches.
As a model of individuals at high risk of cancer we are using HER-2/neu transgenic mice , which spontaneously develop mammary carcinomas, and other transgenic and knockout models.


Gene immunotherapy of cancer

Tumor cells transduced with genes coding for cytokines and surface antigens are used as therapeutic vaccines to stimulate the immune response against tumor and metastasis growth.


Molecular and cellular biology of human musculo-skeletal sarcomas

We study the molecular alterations of human rhabdomyosarcoma and other musculo-skeletal sarcomas, to dissect the mechanisms leading to unrestricted cell growth and to the inhibition of terminal differentiation. We have also developed a transgenic/knockout mouse that spontaneously develops pelvic rhabdomyosrcomas, allowing the study of early events in the natural history of rhabdomyosarcoma


See our recent publications for further details.
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